Ontology highlight
ABSTRACT:
SUBMITTER: Mackler SA
PROVIDER: S-EPMC6772573 | biostudies-literature | 2000 Aug
REPOSITORIES: biostudies-literature
Mackler S A SA Korutla L L Cha X Y XY Koebbe M J MJ Fournier K M KM Bowers M S MS Kalivas P W PW
The Journal of neuroscience : the official journal of the Society for Neuroscience 20000801 16
Levels of the mRNA NAC-1 are increased in the rat forebrain weeks after cocaine exposure. This long-term neuroadaptation occurs during the expression of behavioral sensitization, a model of psychostimulant-induced paranoia. NAC-1, the protein encoded by this cocaine-regulated mRNA, contains a Pox virus and zinc finger/bric-a-brac tramtrack broad complex (POZ/BTB) motif, which mediates interactions among several transcriptional regulators. The present studies demonstrate that NAC-1 acts as a tran ...[more]