Ontology highlight
ABSTRACT:
SUBMITTER: Kaufman BA
PROVIDER: S-EPMC1951767 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Kaufman Brett A BA Durisic Nela N Mativetsky Jeffrey M JM Costantino Santiago S Hancock Mark A MA Grutter Peter P Shoubridge Eric A EA
Molecular biology of the cell 20070620 9
Packaging DNA into condensed structures is integral to the transmission of genomes. The mammalian mitochondrial genome (mtDNA) is a high copy, maternally inherited genome in which mutations cause a variety of multisystem disorders. In all eukaryotic cells, multiple mtDNAs are packaged with protein into spheroid bodies called nucleoids, which are the fundamental units of mtDNA segregation. The mechanism of nucleoid formation, however, remains unknown. Here, we show that the mitochondrial transcri ...[more]