Ontology highlight
ABSTRACT: Background
Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.Methodology/principal findings
Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed.Conclusions/significance
[(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.
SUBMITTER: Diaz LA
PROVIDER: S-EPMC1994593 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Diaz Luis A LA Foss Catherine A CA Thornton Katherine K Nimmagadda Sridhar S Endres Christopher J CJ Uzuner Ovsev O Seyler Thorsten M TM Ulrich Slif D SD Conway Janet J Bettegowda Chetan C Agrawal Nishant N Cheong Ian I Zhang Xiaosong X Ladenson Paul W PW Vogelstein Barry N BN Mont Michael A MA Zhou Shibin S Kinzler Kenneth W KW Vogelstein Bert B Pomper Martin G MG
PloS one 20071010 10
<h4>Background</h4>Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.<h4>Methodol ...[more]