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Imaging of musculoskeletal bacterial infections by [124I]FIAU-PET/CT.


ABSTRACT:

Background

Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.

Methodology/principal findings

Eight subjects with suspected musculoskeletal infections and one healthy control were studied by a combination of [(124)I]FIAU-positron emission tomography and CT ([(124)I]FIAU-PET/CT). All patients with proven musculoskeletal infections demonstrated positive [(124)I]FIAU-PET/CT signals in the sites of concern at two hours after radiopharmaceutical administration. No adverse reactions with FIAU were observed.

Conclusions/significance

[(124)I]FIAU-PET/CT is a promising new method for imaging bacterial infections.

SUBMITTER: Diaz LA 

PROVIDER: S-EPMC1994593 | biostudies-literature | 2007 Oct

REPOSITORIES: biostudies-literature

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<h4>Background</h4>Traditional imaging techniques for the localization and monitoring of bacterial infections, although reasonably sensitive, suffer from a lack of specificity. This is particularly true for musculoskeletal infections. Bacteria possess a thymidine kinase (TK) whose substrate specificity is distinct from that of the major human TK. The substrate specificity difference has been exploited to develop a new imaging technique that can detect the presence of viable bacteria.<h4>Methodol  ...[more]

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