Ontology highlight
ABSTRACT:
SUBMITTER: Ballerini P
PROVIDER: S-EPMC2096658 | biostudies-literature | 2006 Nov
REPOSITORIES: biostudies-literature
Ballerini Patrizia P Ciccarelli Renata R Di Iorio Patrizia P Buccella Silvana S D'Alimonte Iolanda I Giuliani Patricia P Masciulli Arianna A Nargi Eleonora E Beraudi Alina A Rathbone Michel P MP Caciagli Francesco F
Purinergic signalling 20060722 4
The main source of cholesterol in the central nervous system (CNS) is represented by glial cells, mainly astrocytes, which also synthesise and secrete apolipoproteins, in particular apolipoprotein E (ApoE), the major apolipoprotein in the brain, thus generating cholesterol-rich high density lipoproteins (HDLs). This cholesterol trafficking, even though still poorly known, is considered to play a key role in different aspects of neuronal plasticity and in the stabilisation of synaptic transmissio ...[more]