Ontology highlight
ABSTRACT:
SUBMITTER: Watkins NJ
PROVIDER: S-EPMC2168896 | biostudies-literature | 2007 Oct
REPOSITORIES: biostudies-literature
Watkins Nicholas J NJ Lemm Ira I Lührmann Reinhard R
Molecular and cellular biology 20070820 20
Box C/D snoRNPs, factors essential for ribosome biogenesis, are proposed to be assembled in the nucleoplasm before localizing to the nucleolus. However, recent work demonstrated the involvement of nuclear export factors in this process, suggesting that export may take place. Here we show that there are distinct distributions of U8 pre-snoRNAs and pre-snoRNP complexes in HeLa cell nuclear and cytoplasmic extracts. We observed differential association of nuclear export (PHAX, CRM1, and Ran) factor ...[more]