Ontology highlight
ABSTRACT:
SUBMITTER: Ritco-Vonsovici M
PROVIDER: S-EPMC2206973 | biostudies-literature | 2007 Sep
REPOSITORIES: biostudies-literature
Protein science : a publication of the Protein Society 20070727 9
The multifunctional protein, beta-catenin, has essential roles in cell adhesion and, through the Wnt signaling pathway, in controlling cell differentiation, development, and generation of cancer. Could distinct molecular forms of beta-catenin underlie these two functions? Our single-molecule force spectroscopy of armadillo beta-catenin, with molecular dynamics (MD) simulation, suggests a model in which the cell generates various forms of beta-catenin, in equilibrium. We find beta-catenin and the ...[more]