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LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.

ABSTRACT: LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression.

SUBMITTER: Agustiandari H 

PROVIDER: S-EPMC2223683 | biostudies-literature | 2008 Jan

REPOSITORIES: biostudies-literature

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LmrR is a transcriptional repressor of expression of the multidrug ABC transporter LmrCD in Lactococcus lactis.

Agustiandari Herfita H   Lubelski Jacek J   van den Berg van Saparoea H Bart HB   Kuipers Oscar P OP   Driessen Arnold J M AJ  

Journal of bacteriology 20071109 2

LmrCD is an ABC-type multidrug transporter in Lactococcus lactis. LmrR encodes a putative transcriptional regulator. In a DeltalmrR strain, lmrCD is up-regulated. LmrR binds the promoter region of lmrCD and interacts with drugs that cause lmrCD up-regulation. This suggests that LmrR is a drug-dependent transcriptional regulator of lmrCD expression. ...[more]

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