Ontology highlight
ABSTRACT:
SUBMITTER: Takeuchi K
PROVIDER: S-EPMC4235314 | biostudies-literature | 2014 Nov
REPOSITORIES: biostudies-literature
Takeuchi Koh K Tokunaga Yuji Y Imai Misaki M Takahashi Hideo H Shimada Ichio I
Scientific reports 20141118
LmrR is a multidrug transcriptional repressor that controls the expression of a major multidrug transporter, LmrCD, in Lactococcus lactis. However, the molecular mechanism by which LmrR binds to structurally unrelated compounds and is released from the promoter region remains largely unknown. Here, we structurally and dynamically characterized LmrR in the apo, compound-bound and promoter-bound states. The compound-binding site of LmrR exhibits ps-μs dynamics in the apo state, and compound ligati ...[more]