Ontology highlight
ABSTRACT:
SUBMITTER: Kaur S
PROVIDER: S-EPMC2290753 | biostudies-literature | 2008 Mar
REPOSITORIES: biostudies-literature
Kaur Surinder S Sassano Antonella A Dolniak Blazej B Joshi Sonali S Majchrzak-Kita Beata B Baker Darren P DP Hay Nissim N Fish Eleanor N EN Platanias Leonidas C LC
Proceedings of the National Academy of Sciences of the United States of America 20080313 12
Multiple signaling pathways are engaged by the type I and II IFN receptors, but their specific roles and possible coordination in the generation of IFN-mediated biological responses remain unknown. We provide evidence that activation of Akt kinases is required for IFN-inducible engagement of the mTOR/p70 S6 kinase pathway. Our data establish that Akt activity is essential for up-regulation of key IFN-alpha- and IFN-gamma-inducible proteins, which have important functional consequences in the ind ...[more]