Ontology highlight
ABSTRACT:
SUBMITTER: Ishizaki R
PROVIDER: S-EPMC2397321 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Ishizaki Ray R Shin Hye-Won HW Mitsuhashi Hiroko H Nakayama Kazuhisa K
Molecular biology of the cell 20080416 6
BIG2 and BIG1 are closely related guanine-nucleotide exchange factors (GEFs) for ADP-ribosylation factors (ARFs) and are involved in the regulation of membrane traffic through activating ARFs and recruiting coat protein complexes, such as the COPI complex and the AP-1 clathrin adaptor complex. Although both ARF-GEFs are associated mainly with the trans-Golgi network (TGN) and BIG2 is also associated with recycling endosomes, it is unclear whether BIG2 and BIG1 share some roles in membrane traffi ...[more]