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Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

ABSTRACT: The proinflammatory cytokine interleukin 1 (IL-1) activates the transcription of many genes encoding acute phase and proinflammatory proteins, a function mediated primarily by the transcription factor NF-kappaB. An early IL-1 signaling event is the recruitment of the Ser/Thr kinase IRAK to the type I IL-1 receptor (IL-1RI). Here we describe the function of a previously identified IL-1 receptor subunit designated IL-1 receptor accessory protein (IL-1RAcP). IL-1 treatment of cells induces the formation of a complex containing both IL-1RI and IL-1RAcP. IRAK is recruited to this complex through its association with IL-1RAcP. Overexpression of an IL-1RAcP mutant lacking its intracellular domain, the IRAK-binding domain, prevented the recruitment of IRAK to the receptor complex and blocked IL-1-induced NF-kappaB activation.

SUBMITTER: Huang J

PROVIDER: S-EPMC24223 | biostudies-literature | 1997 Nov

REPOSITORIES: biostudies-literature

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Recruitment of IRAK to the interleukin 1 receptor complex requires interleukin 1 receptor accessory protein.

Huang J J Gao X X Li S S Cao Z Z

Proceedings of the National Academy of Sciences of the United States of America 19971101 24

The proinflammatory cytokine interleukin 1 (IL-1) activates the transcription of many genes encoding acute phase and proinflammatory proteins, a function mediated primarily by the transcription factor NF-kappaB. An early IL-1 signaling event is the recruitment of the Ser/Thr kinase IRAK to the type I IL-1 receptor (IL-1RI). Here we describe the function of a previously identified IL-1 receptor subunit designated IL-1 receptor accessory protein (IL-1RAcP). IL-1 treatment of cells induces the form ...[more]

PMID: 9371760

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Interleukin 1 Receptor Accessory Protein

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