Ontology highlight
ABSTRACT:
SUBMITTER: Lakkaraju AK
PROVIDER: S-EPMC2430734 | biostudies-literature | 2008 May
REPOSITORIES: biostudies-literature
Lakkaraju Asvin K K AK Mary Camille C Scherrer Anne A Johnson Arthur E AE Strub Katharina K
Cell 20080501 3
SRP is essential for targeting nascent chains to the endoplasmic reticulum, and it delays nascent chain elongation in cell-free translation systems. However, the significance of this function has remained unclear. We show that efficient protein translocation into the ER is incompatible with normal cellular translation rates due to rate-limiting concentrations of SRP receptor (SR). We complemented mammalian cells depleted of SRP14 by expressing mutant versions of the protein lacking the elongatio ...[more]