Ontology highlight
ABSTRACT:
SUBMITTER: Lee DW
PROVIDER: S-EPMC2441687 | biostudies-literature | 2008 Jul
REPOSITORIES: biostudies-literature
Lee Dong-Won DW Zhao Xiaohong X Yim Yang-In YI Eisenberg Evan E Greene Lois E LE
Molecular biology of the cell 20080423 7
Hsc70 with its cochaperone, either auxilin or GAK, not only uncoats clathrin-coated vesicles but also acts as a chaperone during clathrin-mediated endocytosis. However, because synaptojanin is also involved in uncoating, it is not clear whether GAK is an essential gene. To answer this question, GAK conditional knockout mice were generated and then mated to mice expressing Cre recombinase under the control of the nestin, albumin, or keratin-14 promoters, all of which turn on during embryonic deve ...[more]