Ontology highlight
ABSTRACT:
SUBMITTER: Zhu BM
PROVIDER: S-EPMC2518907 | biostudies-literature | 2008 Sep
REPOSITORIES: biostudies-literature
Zhu Bing-Mei BM McLaughlin Sara K SK Na Risu R Liu Jie J Cui Yongzhi Y Martin Cyril C Kimura Akiko A Robinson Gertraud W GW Andrews Nancy C NC Hennighausen Lothar L
Blood 20080613 5
Iron is essential for all cells but is toxic in excess, so iron absorption and distribution are tightly regulated. Serum iron is bound to transferrin and enters erythroid cells primarily via receptor-mediated endocytosis of the transferrin receptor (Tfr1). Tfr1 is essential for developing erythrocytes and reduced Tfr1 expression is associated with anemia. The transcription factors STAT5A/B are activated by many cytokines, including erythropoietin. Stat5a/b(-/-) mice are severely anemic and die p ...[more]