Ontology highlight
ABSTRACT:
SUBMITTER: Li Y
PROVIDER: S-EPMC3030123 | biostudies-literature | 2009 Jul
REPOSITORIES: biostudies-literature
Immunity 20090701 1
The cytolytic activity of natural killer (NK) cells is regulated by inhibitory receptors that detect the absence of self molecules on target cells. Structural studies of missing self recognition have focused on NK receptors that bind MHC. However, NK cells also possess inhibitory receptors specific for non-MHC ligands, notably cadherins, which are downregulated in metastatic tumors. We determined the structure of killer cell lectin-like receptor G1 (KLRG1) in complex with E-cadherin. KLRG1 media ...[more]