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Asymmetric synthesis of 2H-azirine 3-carboxylates.

ABSTRACT: [reaction: see text] Dehydrochlorination of methyl 2-chloroaziridine 2-carboxylates generates the first examples of enantiopure 2-substituted 2H-azirine 3-carboxylates which undergo the aza Diels-Alder reaction with dienes to give bicyclic and tricyclic aziridines in good yields.

SUBMITTER: Davis FA

PROVIDER: S-EPMC2533708 | biostudies-literature | 2007 Apr

REPOSITORIES: biostudies-literature

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Asymmetric synthesis of 2H-azirine 3-carboxylates.

Davis Franklin A FA Deng Jianghe J

Organic letters 20070327 9

[reaction: see text] Dehydrochlorination of methyl 2-chloroaziridine 2-carboxylates generates the first examples of enantiopure 2-substituted 2H-azirine 3-carboxylates which undergo the aza Diels-Alder reaction with dienes to give bicyclic and tricyclic aziridines in good yields. ...[more]

PMID: 17385874

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