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Convenient Synthesis of Functionalized Cyclopropa[c]coumarin-1a-carboxylates.

ABSTRACT: A simple method has been developed for the synthesis of cyclopropa[c]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring.

SUBMITTER: Ivanova OA

PROVIDER: S-EPMC6337311 | biostudies-literature | 2018 Dec

REPOSITORIES: biostudies-literature

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Convenient Synthesis of Functionalized Cyclopropa[<i>c</i>]coumarin-1a-carboxylates.

Ivanova Olga A OA Andronov Vladimir A VA Levina Irina I II Chagarovskiy Alexey O AO Voskressensky Leonid G LG Trushkov Igor V IV

Molecules (Basel, Switzerland) 20181224 1

A simple method has been developed for the synthesis of cyclopropa[<i>c</i>]coumarins, which belong to the donor-acceptor cyclopropane family and, therefore, are promising substrates for the preparation of chromene-based fine chemicals. The method, based on the acetic acid-induced intramolecular transesterification of 2-arylcyclopropane-1,1-dicarboxylates, was found to be efficient for substrates containing hydroxy group directly attached to the aromatic ring. ...[more]

PMID: 30586901

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