Ontology highlight
ABSTRACT:
SUBMITTER: Chadda R
PROVIDER: S-EPMC5010387 | biostudies-literature | 2016 Aug
REPOSITORIES: biostudies-literature
Chadda Rahul R Krishnamani Venkatramanan V Mersch Kacey K Wong Jason J Brimberry Marley M Chadda Ankita A Kolmakova-Partensky Ludmila L Friedman Larry J LJ Gelles Jeff J Robertson Janice L JL
eLife 20160803
Interactions between membrane protein interfaces in lipid bilayers play an important role in membrane protein folding but quantification of the strength of these interactions has been challenging. Studying dimerization of ClC-type transporters offers a new approach to the problem, as individual subunits adopt a stable and functionally verifiable fold that constrains the system to two states - monomer or dimer. Here, we use single-molecule photobleaching analysis to measure the probability of ClC ...[more]