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Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma.

ABSTRACT: Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment (odds ratio 7.88, 95% confidential interval 1.51-41.04) when compared to AA patients. Our data supports the possible involvement of LEP-2548G/A polymorphism in CTCL treatment responsiveness and thus might provide important information for individual therapy tailoring.

SUBMITTER: Vasku V

PROVIDER: S-EPMC2583633 | biostudies-literature | 2009

REPOSITORIES: biostudies-literature

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Pharmacogenetic contribution of leptin gene polymorphism in cutaneous T-cell lymphoma.

Vasku Vladimir V Vasku Anna A Vasku Julie Bienertova JB

International journal of clinical and experimental pathology 20080718 2

Leptin has recently attracted more attention due to its specific effects in the pathogenesis of malignancies. The aim of this study was to investigate the possible association between variants of -2548 G/A polymorphism in leptin (LEP) gene and cutaneous T-cell lymphomas (CTCL), with respect to the treatment responsiveness. A sample of 91 patients with CTCL was compared to 198 control individuals. The CTCL men with AG and/or GG genotype were more likely to receive the topical steroids treatment ( ...[more]

PMID: 19079651

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