Distinct gating modes determine the biphasic relaxation of NMDA receptor currents.
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ABSTRACT:
SUBMITTER: Zhang W
PROVIDER: S-EPMC2587015 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Distinct gating modes determine the biphasic relaxation of NMDA receptor currents.
Zhang Wei W Howe James R JR Popescu Gabriela K GK
Nature neuroscience 20081026 12
Following brief stimulation, macroscopic NMDA receptor currents decay with biphasic kinetics that is believed to reflect glutamate dissociation and receptor desensitization. We found that the fast and slow decay components arise from the simultaneous deactivation of receptor populations that gate with short and long openings, respectively. Because individual receptors switched infrequently between gating modes, the relaxation time course was largely determined by the proportion of channels in ea ...[more]
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