Ontology highlight
ABSTRACT:
SUBMITTER: Oak JS
PROVIDER: S-EPMC2804088 | biostudies-literature | 2009 Aug
REPOSITORIES: biostudies-literature
Oak Jean S JS Chen Jing J Peralta Raechel Q RQ Deane Jonathan A JA Fruman David A DA
Autoimmunity 20090801 5
Phosphoinositide kinase (PI3K) is activated by various receptors on lymphocytes and regulates development, activation, and tolerance. Genetic ablation of PI3K function in T cells leads to the appearance of autoimmune disorders. In B cells, loss of the class IA regulatory subunit p85alpha causes a partial defect in B cell development and proliferation, whereas loss of p85beta alone causes no apparent changes in B cell function. Here we investigate further the consequences of p85beta deletion in B ...[more]