Heterotrimeric coiled coils with core residue urea side chains.
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ABSTRACT:
SUBMITTER: Diss ML
PROVIDER: S-EPMC2656609 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Publications
Heterotrimeric coiled coils with core residue urea side chains.
Diss Maria L ML Kennan Alan J AJ
The Journal of organic chemistry 20081201 24
We report several coiled coil heterotrimers with varying core residue buried polar groups, all with T(m) values >43 degrees C. Introduction of new synthetic side chain structures, including some terminating in monosubstituted ureas, diversifies the pool of viable core residue candidates. A study of core charge pairings demonstrates that, unlike dimeric systems, trimeric coiled coils do not tolerate guanidine-guanidine contacts, even in the presence of a compensating carboxylate. Overall, the ros ...[more]
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