Predicting coiled coils by use of pairwise residue correlations.
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ABSTRACT:
SUBMITTER: Berger B
PROVIDER: S-EPMC41136 | biostudies-other | 1995 Aug
REPOSITORIES: biostudies-other
Publications
Predicting coiled coils by use of pairwise residue correlations.
Berger B B Wilson D B DB Wolf E E Tonchev T T Milla M M Kim P S PS
Proceedings of the National Academy of Sciences of the United States of America 19950801 18
A method is presented that predicts coiled-coil domains in protein sequences by using pairwise residue correlations obtained from a (two-stranded) coiled-coil database of 58,217 amino acid residues. A program called PAIRCOIL implements this method and is significantly better than existing methods at distinguishing coiled coils from alpha-helices that are not coiled coils. The database of pairwise residue correlations suggests structural features that stabilize or destabilize coiled coils. ...[more]
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