Ontology highlight
ABSTRACT:
SUBMITTER: Gross H
PROVIDER: S-EPMC2668242 | biostudies-literature | 2006 Apr
REPOSITORIES: biostudies-literature
Journal of natural products 20060401 4
Lophocladines A (1) and B (2), two 2,7-naphthyridine alkaloids, were isolated from the marine red alga Lophocladiasp. collected in the Fijian Islands. Their structures were deduced on the basis of high-resolution mass spectra and one- and two-dimensional NMR spectroscopy. Lophocladine A (1) displayed affinity for NMDA receptors and was found to be a delta-opioid receptor antagonist, whereas lophocladine B (2) exhibited cytotoxicity to NCI-H460 human lung tumor and MDA-MB-435 breast cancer cell l ...[more]