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Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

ABSTRACT: Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum.

SUBMITTER: Lin AS

PROVIDER: S-EPMC3375676 | biostudies-literature | 2010 Feb

REPOSITORIES: biostudies-literature

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Bioactive bromophycolides R-U from the Fijian red alga Callophycus serratus.

Lin An-Shen AS Stout E Paige EP Prudhomme Jacques J Le Roch Karine K Fairchild Craig R CR Franzblau Scott G SG Aalbersberg William W Hay Mark E ME Kubanek Julia J

Journal of natural products 20100201 2

Four new bromophycolides, R-U (1-4), were isolated from the Fijian red alga Callophycus serratus and were identified by 1D and 2D NMR and mass spectroscopic analyses. These compounds expand the known structural variety of diterpene-benzoate macrolides and exhibited modest cytotoxicity toward selected human cancer cell lines. Bromophycolide S (2) also showed submicromolar activity against the human malaria parasite Plasmodium falciparum. ...[more]

PMID: 20141173

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