Ontology highlight
ABSTRACT:
SUBMITTER: Jimi E
PROVIDER: S-EPMC2670481 | biostudies-literature | 2008 Oct
REPOSITORIES: biostudies-literature
Jimi Eijiro E Strickland Ian I Voll Reinhard E RE Long Meixiao M Ghosh Sankar S
Immunity 20081001 4
Inhibition of the transcription factor nuclear factor (NF)-kappaB activity leads to a reduction in numbers of CD8(+) single-positive (SP) thymocytes, suggesting a selective role for NF-kappaB in these cells. To further explore the role of NF-kappaB in SP thymocytes, we utilized transgenic models that allowed either inhibition or activation of NF-kappaB. We showed that activation of NF-kappaB played an important role in the selection of major histocompatibility complex (MHC) class I-restricted CD ...[more]