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Aquaporin-2 in the "-omics" era.

ABSTRACT: Vasopressin controls renal water excretion largely through actions to regulate the water channel aquaporin-2 in collecting duct principal cells. Our knowledge of the mechanisms involved has increased markedly in recent years with the advent of methods for large-scale systems-level profiling such as protein mass spectrometry, yeast two-hybrid analysis, and oligonucleotide microarrays. Here we review this progress.

SUBMITTER: Hoffert JD 

PROVIDER: S-EPMC2685649 | biostudies-literature | 2009 May

REPOSITORIES: biostudies-literature

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Aquaporin-2 in the "-omics" era.

Hoffert Jason D JD   Chou Chung-Lin CL   Knepper Mark A MA  

The Journal of biological chemistry 20090204 22

Vasopressin controls renal water excretion largely through actions to regulate the water channel aquaporin-2 in collecting duct principal cells. Our knowledge of the mechanisms involved has increased markedly in recent years with the advent of methods for large-scale systems-level profiling such as protein mass spectrometry, yeast two-hybrid analysis, and oligonucleotide microarrays. Here we review this progress. ...[more]

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