Ontology highlight
ABSTRACT:
SUBMITTER: Bierie B
PROVIDER: S-EPMC2689133 | biostudies-literature | 2009 Jun
REPOSITORIES: biostudies-literature
Bierie Brian B Chung Christine H CH Parker Joel S JS Stover Daniel G DG Cheng Nikki N Chytil Anna A Aakre Mary M Shyr Yu Y Moses Harold L HL
The Journal of clinical investigation 20090518 6
In human breast cancer, loss of carcinoma cell-specific response to TGF-beta signaling has been linked to poor patient prognosis. However, the mechanisms through which TGF-beta regulates these processes remain largely unknown. In an effort to address this issue, we have now identified gene expression signatures associated with the TGF-beta signaling pathway in human mammary carcinoma cells. The results strongly suggest that TGF-beta signaling mediates intrinsic, stromal-epithelial, and host-tumo ...[more]