Ontology highlight
ABSTRACT:
SUBMITTER: Gate D
PROVIDER: S-EPMC4143044 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Gate David D Danielpour Moise M Rodriguez Javier J Kim Gi-Bum GB Levy Rachelle R Bannykh Serguei S Breunig Joshua J JJ Kaech Susan M SM Flavell Richard A RA Town Terrence T
Proceedings of the National Academy of Sciences of the United States of America 20140731 33
Cancer cell secretion of TGF-β is a potent mechanism for immune evasion. However, little is known about how central nervous system tumors guard against immune eradication. We sought to determine the impact of T-cell TGF-β signaling blockade on progression of medulloblastoma (MB), the most common pediatric brain tumor. Genetic abrogation of T-cell TGF-β signaling mitigated tumor progression in the smoothened A1 (SmoA1) transgenic MB mouse. T regulatory cells were nearly abolished and antitumor im ...[more]