Ontology highlight
ABSTRACT:
SUBMITTER: Yue J
PROVIDER: S-EPMC5476826 | biostudies-literature | 2016 May
REPOSITORIES: biostudies-literature
Nature communications 20160524
Turnover of focal adhesions allows cell retraction, which is essential for cell migration. The mammalian spectraplakin protein, ACF7 (Actin-Crosslinking Factor 7), promotes focal adhesion dynamics by targeting of microtubule plus ends towards focal adhesions. However, it remains unclear how the activity of ACF7 is regulated spatiotemporally to achieve focal adhesion-specific guidance of microtubule. To explore the potential mechanisms, we resolve the crystal structure of ACF7's NT (amino-termina ...[more]