Ontology highlight
ABSTRACT:
SUBMITTER: Browne LE
PROVIDER: S-EPMC2954318 | biostudies-literature | 2010 May
REPOSITORIES: biostudies-literature
Browne Liam E LE Jiang Lin-Hua LH North R Alan RA
Trends in pharmacological sciences 20100311 5
P2X receptors are ATP-gated membrane ion channels with multifarious roles, including afferent sensation, autocrine feedback loops, and inflammation. Their molecular operation has been less well elucidated compared with other ligand-gated channels (nicotinic acetylcholine receptors, ionotropic glutamate receptors). This will change with the recent publication of the crystal structure of a closed P2X receptor. Here we re-interpret results from 15 years of experiments using site-directed mutagenesi ...[more]