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Steric modulation of chiral biaryl diamines via Pd-catalyzed directed C-H arylation.

ABSTRACT: Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para- and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis.

SUBMITTER: Scarborough CC

PROVIDER: S-EPMC2726659 | biostudies-literature | 2009 Mar

REPOSITORIES: biostudies-literature

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Steric modulation of chiral biaryl diamines via Pd-catalyzed directed C-H arylation.

Scarborough Christopher C CC McDonald Richard I RI Hartmann Caroline C Sazama Graham T GT Bergant Ana A Stahl Shannon S SS

The Journal of organic chemistry 20090301 6

Palladium-catalyzed directed arylation of 2,2'-diacetamidobiaryls with aryl iodides provides efficient access to chiral ortho-substituted biaryl diamines. Aryl iodides with para- and meta-substituents are tolerated. Deprotection of the acetyl groups under basic conditions furnishes the free diamines, which should find broad utility in asymmetric catalysis. ...[more]

PMID: 19219972

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