Ontology highlight
ABSTRACT:
SUBMITTER: Tomlins SA
PROVIDER: S-EPMC2732022 | biostudies-literature | 2008 Jun
REPOSITORIES: biostudies-literature
Tomlins Scott A SA Rhodes Daniel R DR Yu Jianjun J Varambally Sooryanarayana S Mehra Rohit R Perner Sven S Demichelis Francesca F Helgeson Beth E BE Laxman Bharathi B Morris David S DS Cao Qi Q Cao Xuhong X Andrén Ove O Fall Katja K Johnson Laura L Wei John T JT Shah Rajal B RB Al-Ahmadie Hikmat H Eastham James A JA Eggener Scott E SE Fine Samson W SW Hotakainen Kristina K Stenman Ulf-Håkan UH Tsodikov Alex A Gerald William L WL Lilja Hans H Reuter Victor E VE Kantoff Phillip W PW Scardino Peter T PT Rubin Mark A MA Bjartell Anders S AS Chinnaiyan Arul M AM
Cancer cell 20080601 6
ETS gene fusions have been characterized in a majority of prostate cancers; however, the key molecular alterations in ETS-negative cancers are unclear. Here we used an outlier meta-analysis (meta-COPA) to identify SPINK1 outlier expression exclusively in a subset of ETS rearrangement-negative cancers ( approximately 10% of total cases). We validated the mutual exclusivity of SPINK1 expression and ETS fusion status, demonstrated that SPINK1 outlier expression can be detected noninvasively in urin ...[more]