Ontology highlight
ABSTRACT:
SUBMITTER: Annala M
PROVIDER: S-EPMC4467434 | biostudies-literature | 2015 Mar
REPOSITORIES: biostudies-literature
Annala Matti M Kivinummi Kati K Tuominen Joonas J Karakurt Serdar S Granberg Kirsi K Latonen Leena L Ylipää Antti A Sjöblom Liisa L Ruusuvuori Pekka P Saramäki Outi O Kaukoniemi Kirsi M KM Yli-Harja Olli O Vessella Robert L RL Tammela Teuvo L J TL Zhang Wei W Visakorpi Tapio T Nykter Matti M
Oncotarget 20150301 8
Prostate cancer is the third most common cause of male cancer death in developed countries, and one of the most comprehensively characterized human cancers. Roughly 60% of prostate cancers harbor gene fusions that juxtapose ETS-family transcription factors with androgen regulated promoters. A second subtype, characterized by SPINK1 overexpression, accounts for 15% of prostate cancers. Here we report the discovery of a new prostate cancer subtype characterized by rearrangements juxtaposing the SM ...[more]