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Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.

ABSTRACT: Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening.

SUBMITTER: Nieto S

PROVIDER: S-EPMC2749327 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Rapid enantiomeric excess and concentration determination using simple racemic metal complexes.

Nieto Sonia S Lynch Vincent M VM Anslyn Eric V EV Kim Hyunwoo H Chin Jik J

Organic letters 20081022 22

Racemic-metal complexes were used to determine identity, enantiomeric excess, and concentration of chiral diamines using metal-to-ligand charge transfer bands in circular dichroism spectroscopy. It takes under just 2 min per sample to determine [G]t and %R with tolerable errors (19% and 4%, respectively). The simplicity of the achiral receptors employed confers to this technique great potential for high-throughput screening. ...[more]

PMID: 18939802

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