Restricting dosage compensation complex binding to the X chromosomes by H2A.Z/HTZ-1.

ABSTRACT: Dosage compensation ensures similar levels of X-linked gene products in males (XY or XO) and females (XX), despite their different numbers of X chromosomes. In mammals, flies, and worms, dosage compensation is mediated by a specialized machinery that localizes to one or both of the X chromosomes in one sex resulting in a change in gene expression from the affected X chromosome(s). In mammals and flies, dosage compensation is associated with specific histone posttranslational modifications and replacement with variant histones. Until now, no specific histone modifications or histone variants have been implicated in Caenorhabditis elegans dosage compensation. Taking a candidate approach, we have looked at specific histone modifications and variants on the C. elegans dosage compensated X chro

SUBMITTER: Petty EL 

PROVIDER: S-EPMC2760203 | biostudies-literature | 2009 Oct

REPOSITORIES: biostudies-literature