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Microscopes for fluorimeters: the era of single molecule measurements.

ABSTRACT: As transforming as the first atomic resolution view of myoglobin in the late 1950s, scientists can now use a suite of single molecule technologies to watch protein macromolecular machines executing their functions "in real time." This Essay highlights applications and challenges of single molecule studies in structural biology, cell biology, and biotechnology.

SUBMITTER: Vale RD 

PROVIDER: S-EPMC2762818 | biostudies-literature | 2008 Nov

REPOSITORIES: biostudies-literature

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Microscopes for fluorimeters: the era of single molecule measurements.

Vale Ronald D RD  

Cell 20081101 5

As transforming as the first atomic resolution view of myoglobin in the late 1950s, scientists can now use a suite of single molecule technologies to watch protein macromolecular machines executing their functions "in real time." This Essay highlights applications and challenges of single molecule studies in structural biology, cell biology, and biotechnology. ...[more]

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