Ontology highlight
ABSTRACT:
SUBMITTER: Mito JK
PROVIDER: S-EPMC2779485 | biostudies-literature | 2009 Nov
REPOSITORIES: biostudies-literature
PloS one 20091130 11
Undifferentiated pleomorphic sarcoma/Malignant Fibrous Histiocytoma (MFH) is one of the most common subtypes of human soft tissue sarcoma. Using cross species genomic analysis, we define a geneset from the LSL-Kras(G12D); Trp53(Flox/Flox) mouse model of soft tissue sarcoma that is highly enriched in human MFH. With this mouse geneset as a filter, we identify expression of the RAS target FOXM1 in human MFH. Expression of Foxm1 is elevated in mouse sarcomas that metastasize to the lung and tissue ...[more]