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Nickel-catalyzed cycloadditive couplings of enynes and isocyanates.


ABSTRACT: A mild and general route for preparing dienamides is described. Nickel imidazolylidene complexes were used to mediate cycloadditive coupling between enynes and isocyanates. Dienamides were prepared in excellent yields and with good E:Z selectivity. These dienamides can be further manipulated through oxidative cyclization methods. When a terminal enyne is employed, cyclization affords a lactam rather than a dienamide.

SUBMITTER: D'Souza BR 

PROVIDER: S-EPMC2792207 | biostudies-literature | 2009 Sep

REPOSITORIES: biostudies-literature

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Nickel-catalyzed cycloadditive couplings of enynes and isocyanates.

D'Souza Brendan R BR   Louie Janis J  

Organic letters 20090901 18


A mild and general route for preparing dienamides is described. Nickel imidazolylidene complexes were used to mediate cycloadditive coupling between enynes and isocyanates. Dienamides were prepared in excellent yields and with good E:Z selectivity. These dienamides can be further manipulated through oxidative cyclization methods. When a terminal enyne is employed, cyclization affords a lactam rather than a dienamide. ...[more]

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