Ontology highlight
ABSTRACT:
SUBMITTER: Isaacs A
PROVIDER: S-EPMC2797851 | biostudies-literature | 2007
REPOSITORIES: biostudies-literature
Isaacs Aaron A Sayed-Tabatabaei Fakhredin A FA Aulchenko Yurii S YS Zillikens M Carola MC Sijbrands Eric J G EJ Schut Anna F C AF Rutten Wim P F WP Pols Huibert A P HA Witteman Jacqueline C M JC Oostra Ben A BA van Duijn Cornelia M CM
European journal of epidemiology 20070221 2
Despite considerable progress in unravelling the genetic basis of dyslipidemias, most findings are based on families with extreme phenotypes. We studied lipid levels in an extended pedigree ascertained irrespective of phenotype from the population of a recent genetic isolate in the Netherlands. Heritabilities of plasma lipid measures were examined; this analysis also included estimates of the proportion of variance attributable to ApoE genotype. The association between inbreeding and lipids was ...[more]