Ontology highlight
ABSTRACT:
SUBMITTER: Liu X
PROVIDER: S-EPMC2813267 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20091112 5962
Previous x-ray crystal structures have given insight into the mechanism of transcription and the role of general transcription factors in the initiation of the process. A structure of an RNA polymerase II-general transcription factor TFIIB complex at 4.5 angstrom resolution revealed the amino-terminal region of TFIIB, including a loop termed the "B finger," reaching into the active center of the polymerase where it may interact with both DNA and RNA, but this structure showed little of the carbo ...[more]