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IAP regulation of metastasis.

ABSTRACT: Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinases FAK and Src. Therefore, IAPs are direct metastasis genes, and their antagonists could provide antimetastatic therapies in patients with cancer.

SUBMITTER: Mehrotra S

PROVIDER: S-EPMC2818597 | biostudies-literature | 2010 Jan

REPOSITORIES: biostudies-literature

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IAP regulation of metastasis.

Mehrotra Swarna S Languino Lucia R LR Raskett Christopher M CM Mercurio Arthur M AM Dohi Takehiko T Altieri Dario C DC

Cancer cell 20100101 1

Inhibitor-of-Apoptosis (IAP) proteins contribute to tumor progression, but the requirements of this pathway are not understood. Here, we show that intermolecular cooperation between XIAP and survivin stimulates tumor cell invasion and promotes metastasis. This pathway is independent of IAP inhibition of cell death. Instead, a survivin-XIAP complex activates NF-kappaB, which in turn leads to increased fibronectin gene expression, signaling by beta1 integrins, and activation of cell motility kinas ...[more]

PMID: 20129247

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Regulation of innate and adaptive antitumor immunity by IAP antagonists.

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The IAP Antagonist SM-164 Eliminates Triple-Negative Breast Cancer Metastasis to Bone and Lung in Mice.

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2015-02-09 | E-GEOD-64927 | biostudies-arrayexpress

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Effects of physiological and synthetic IAP antagonism on c-IAP-dependent signaling.

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