Ontology highlight
ABSTRACT:
SUBMITTER: Lin HJ
PROVIDER: S-EPMC2821873 | biostudies-literature | 2008 Dec
REPOSITORIES: biostudies-literature
Lin Huey-Jen L HJ Zuo Tao T Zuo Tao T Lin Ching-Hung CH Kuo Chieh Ti CT Liyanarachchi Sandya S Sun Shuying S Shen Rulong R Deatherage Daniel E DE Potter Dustin D Asamoto Lisa L Lin Shili S Yan Pearlly S PS Cheng Ann-Lii AL Ostrowski Michael C MC Huang Tim H-M TH
Cancer research 20081201 24
The interplay between histone modifications and promoter hypermethylation provides a causative explanation for epigenetic gene silencing in cancer. Less is known about the upstream initiators that direct this process. Here, we report that the Cystatin M (CST6) tumor suppressor gene is concurrently down-regulated with other loci in breast epithelial cells cocultured with cancer-associated fibroblasts (CAF). Promoter hypermethylation of CST6 is associated with aberrant AKT1 activation in epithelia ...[more]