Ontology highlight
ABSTRACT:
SUBMITTER: Brailoiu E
PROVIDER: S-EPMC2823445 | biostudies-literature | 2010 Jan
REPOSITORIES: biostudies-literature
Brailoiu Eugen E Hooper Robert R Cai Xinjiang X Brailoiu G Cristina GC Keebler Michael V MV Dun Nae J NJ Marchant Jonathan S JS Patel Sandip S
The Journal of biological chemistry 20091125 5
Nicotinic acid adenine dinucleotide phosphate (NAADP) is a potent and widespread calcium-mobilizing messenger, the properties of which have been most extensively described in sea urchin eggs. The molecular basis for calcium release by NAADP, however, is not clear and subject to controversy. Recent studies have provided evidence that members of the two-pore channel (TPC) family in mammals are the long sought after target channels for NAADP. Here, we show that the TPC3 gene, which has yet to be fu ...[more]