Ontology highlight
ABSTRACT:
SUBMITTER: Mahankali M
PROVIDER: S-EPMC4311130 | biostudies-literature | 2015 Feb
REPOSITORIES: biostudies-literature
Mahankali Madhu M Henkels Karen M KM Speranza Francis F Gomez-Cambronero Julian J
Journal of cell science 20150201 3
Timely activation of Aurora kinase A (AURA, also known as AURKA) is vital for centrosome formation and the progression of mitosis. Nonetheless, it is still unclear if and when other cellular functions are activated by AURA. We report here that Src phosphorylates and activates AURA at T288, and AURA also activates focal adhesion kinase (FAK, also known as PTK2), leading to initiation of cell movement. An additional and new way by which AURA is regulated, is by phospholipase D2 (PLD2), which cause ...[more]