Ontology highlight
ABSTRACT:
SUBMITTER: Barretto RP
PROVIDER: S-EPMC3833825 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Barretto Robert P J RP Ko Tony H TH Jung Juergen C JC Wang Tammy J TJ Capps George G Waters Allison C AC Ziv Yaniv Y Attardo Alessio A Recht Lawrence L Schnitzer Mark J MJ
Nature medicine 20110116 2
The combination of intravital microscopy and animal models of disease has propelled studies of disease mechanisms and treatments. However, many disorders afflict tissues inaccessible to light microscopy in live subjects. Here we introduce cellular-level time-lapse imaging deep within the live mammalian brain by one- and two-photon fluorescence microendoscopy over multiple weeks. Bilateral imaging sites allowed longitudinal comparisons within individual subjects, including of normal and diseased ...[more]