Ontology highlight
ABSTRACT:
SUBMITTER: Eichner J
PROVIDER: S-EPMC2829161 | biostudies-literature | 2010 Feb
REPOSITORIES: biostudies-literature
Eichner Jesse J Chen Hung-Ta HT Warfield Linda L Hahn Steven S
The EMBO journal 20091224 4
The RNA polymerase (pol) II general transcription factor TFIIF functions at several steps in transcription initiation including preinitiation complex (PIC) formation and start site selection. We find that two structured TFIIF domains bind Pol II at separate locations far from the active site with the TFIIF dimerization domain on the Pol II lobe and the winged helix domain of the TFIIF small subunit Tfg2 above the Pol II protrusion where it may interact with upstream promoter DNA. Binding of the ...[more]