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Antistaphylococcal activities of telavancin tested alone and in combination by time-kill assay.

ABSTRACT: Synergy time-kill studies against 40 methicillin-resistant Staphylococcus aureus (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of other antimicrobial agents that might be used in combination with telavancin to provide Gram-negative coverage. The highest incidence of synergy was found after 24 h with gentamicin (90% of strains), followed by ceftriaxone (88%), rifampin and meropenem (each 65%), cefepime (45%), and ciprofloxacin (38%) for combinations tested at or below the intermediate breakpoint for each agent.

SUBMITTER: Lin G

PROVIDER: S-EPMC2863621 | biostudies-literature | 2010 May

REPOSITORIES: biostudies-literature

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Antistaphylococcal activities of telavancin tested alone and in combination by time-kill assay.

Lin Gengrong G Pankuch Glenn A GA Ednie Lois M LM Appelbaum Peter C PC

Antimicrobial agents and chemotherapy 20100216 5

Synergy time-kill studies against 40 methicillin-resistant Staphylococcus aureus (MRSA) strains of differing resistance phenotypes were conducted. Subinhibitory concentrations of telavancin were combined with sub-MIC concentrations of other antimicrobial agents that might be used in combination with telavancin to provide Gram-negative coverage. The highest incidence of synergy was found after 24 h with gentamicin (90% of strains), followed by ceftriaxone (88%), rifampin and meropenem (each 65%), ...[more]

PMID: 20160048

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