Unknown

Dataset Information

0

Copper(I)-Catalyzed Cross-Coupling of 1-Bromoalkynes with N-Heterocyclic Organozinc Reagents.


ABSTRACT: Nitrogen-containing heterocycles represent the majority of FDA-approved small-molecule pharmaceuticals. Herein, we describe a synthetic method to produce saturated N-heterocyclic drug scaffolds with an internal alkyne for elaboration. The treatment of N,N-dimethylhydrazinoalkenes with Et2Zn, followed by a Cu(I)-catalyzed cross-coupling with 1-bromoalkynes, results in piperidines and pyrrolidines with a good yield. Five examples are reported and a proposed mechanism for the Cu(I)-catalyzed cross-coupling is presented.

SUBMITTER: Frabitore C 

PROVIDER: S-EPMC9315687 | biostudies-literature |

REPOSITORIES: biostudies-literature

Similar Datasets

| S-EPMC4660974 | biostudies-literature
| S-EPMC6764867 | biostudies-literature
| S-EPMC4260645 | biostudies-literature
| S-EPMC4552333 | biostudies-literature
| S-EPMC2865154 | biostudies-literature
| S-EPMC7418105 | biostudies-literature
| S-EPMC5984048 | biostudies-literature
| S-EPMC6365418 | biostudies-literature
| S-EPMC2860276 | biostudies-literature
| S-EPMC3359135 | biostudies-literature