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A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.

ABSTRACT: A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported.

SUBMITTER: Ju L

PROVIDER: S-EPMC2907649 | biostudies-literature | 2009 Jun

REPOSITORIES: biostudies-literature

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A general strategy for the preparation of C-terminal peptide alpha-ketoacids by solid phase peptide synthesis.

Ju Lei L Bode Jeffrey W JW

Organic & biomolecular chemistry 20090402 11

A new cyanosulfur-ylide based linker makes possible the synthesis of C-terminal peptide alpha-ketoacids by solid phase synthesis. The preparation of the requisite linker and its application to a variety of C-terminal peptide alpha-ketoacids with unprotected side chains is reported. ...[more]

PMID: 19462032

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